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KMID : 0379520040200010055
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한국독성학회지
2004 Volume.20 No. 1 p.55 ~ p.61
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Changes of Pulmonary Function!) During 60 days of Welding Fume Exposure Period 1m Sprague-Dawley Rats
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Sung Jae-Hyuk
Choi Byung-Gil
Maeng Seung-Hee
Kim Soo-Jin
Chung Yong-Hyun
Han Jeong-Hee
Hyun Jin-Suk
Song Kyung-Seuk
Cho Young-Bong
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Abstract
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Respiratory effects in full time welders include bronchitis, airway irritation, lung function changes, and lung fibrosis. Welder’s pneumoconiosis has been generally determined to be benign and not associated with respiratory symptoms based on the absence of pulmonary function abnormalities in welders with marked radiographic abnormalities. Accordingly, to investigate pulmonary function changes during 60 days induced by welding-fume exposure, male Sprague-Dawley rats were exposed to manual metal arc-stainless steel (MMA-SS) welding fumes with concentrations of 64.8pm0.9 mg/m^3 (low dose) and 107.8 pm 2.6 mg/m^3 (high dose) total suspended particulates for 2 hr/day, 5 days/week in an inhalation chamber for 60 days. Pulmonary function was measured every week with whole body plethysmograph compensated (WBP Comp, SFT38116, Buxco Electronics, Sharon, CT). The rats exposed to the high dose of welding fumes exhibited statistically significant (p<0.05~0.01) body weight decrease as compared to the control whereas cell number increase of the bronchoalveolar lavage fluid (BALF) (total cell, macrophage, polymorphonuclear cell and lymphocyte) during the 60 days exposure period. And only tidal volume was significantly decreased in dosedependantly during 60 days of MMA-SS welding fume exposure. This pulmonary function change with inflammatory cell recruitment confirms the lung injury caused by the MMA-SS welding fume exposure.
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KEYWORD
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Pulmonary function test, Welding fume, Bronchoalveolar lavage, Tidal volume, Welder’s pnuemoconiosis, Lung fibrosis.
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